Brand  (β version)

PDB ID: 5WAL

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Ligands
Code Name Style Show Link
9ZS N-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-C]pyridin-4-yl]cyclopropanecarboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5WAL   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Release Data : 2017-09-06
Compound :
mol_id molecule chains
1 Non-receptor tyrosine-protein kinase TYK2 A
ec: 2.7.10.2
mutation: C936A, Q969A, E971A, K972A, S1016A, C1142A, D1023N
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: TYK2
Authors : Ultsch, M.H., Magnuson, S.
Keywords : Tyk2, Kinase, Inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.45 Å )
Citation :

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

Liang, J.,Van Abbema, A.,Balazs, M.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 4370 - 4376

PubMed: 28830649
DOI: 10.1016/j.bmcl.2017.08.022

Reaction

Chain : A
UniProt : P29597 (TYK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PubMed:10542297, PubMed:7526154
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