Brand  (β version)

PDB ID: 5WA9

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Ligands
Code Name Style Show Link
9ZD [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid PoSSuM
CL Chloride ion PoSSuM
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Structure summary

Code : 5WA9   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex
Release Data : 2017-10-18
Compound :
mol_id molecule chains synonym
1 Histidine triad nucleotide-binding protein 1 A,B Adenosine 5'-monophosphoramidase,Protein kinase C inhibitor 1,Protein kinase C-interacting protein 1,PKCI-1
ec: 3.-.-.-
mutation: H112N
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HINT1, HINT, PKCI1, PRKCNH1
expression_system_strain: Rosetta 2 pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG7
Authors : Maize, K.M., Finzel, B.C.
Keywords : histidine triad, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.1500 Å )
Citation :

A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.

Maize, K.M.,Shah, R.,Strom, A.  et al.
(2017)  Mol. Pharm.  14 : 3987 - 3997

PubMed: 28968488
DOI: 10.1021/acs.molpharmaceut.7b00664

Reaction

Chain : A, B
UniProt : P49773 (HINT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
adenosine 5'-phosphoramidate + H2O = AMP + NH4(+) - PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367
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