Het-PDB Navi2 (PDB: 5W92)

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Ligands
Code	Name	Link
MN	Manganese (II) ion	PoSSuM
KU0	2-[(2s)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide	PoSSuM
9HD	1-[(3r,5s,7r)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2h-pyrrol-2-one	PoSSuM

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Download interaction data: 5W92

Code :

5W92 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30049

Release Data :

2018-02-07

Compound :

mol_id	molecule	chains
1	Polymerase acidic protein	A

Source :

mol_id	organism_scientific	expression_system
1	Influenza A virus (taxid:641501)	Escherichia coli (taxid:469008)
	strain: swl A/California/04/2009 H1N1 gene: PA expression_system_strain: BL21 (DE3)

Authors :

Kumar, G., White, S.

Keywords :

Virus, Nuclease, Transcription, Cap-snatching, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.3000 Å )

Citation :

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.

Beylkin, D.,Kumar, G.,Zhou, W. et al.
(2017) Sci Rep 7 : 17139 - 17139

PDB ID: 5W92