Brand  (β version)

PDB ID: 5W8V

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Ligands
Code Name Style Show Link
9YP {[(2r)-2-[(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5W8V   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid
Release Data : 2017-08-30
Compound :
mol_id molecule chains synonym
1 Hypoxanthine-guanine phosphoribosyltransferase A,B,C,D HGPRTase
ec: 2.4.2.8
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HPRT1, HPRT
Authors : Guddat, L.W., Keough, D.T.
Keywords : 6-oxopurine; phosphoribosyltransferase; hypoxanthine; guanine; nucleoside phosphonate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.346 Å )
Citation :

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

Spacek, P.,Keough, D.T.,Chavchich, M.  et al.
(2017)  J. Med. Chem.  60 : 7539 - 7554

PubMed: 28813147
DOI: 10.1021/acs.jmedchem.7b00926

Reaction

Chain : A, B, C, D
UniProt : P00492 (HPRT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1- diphosphate 2.4.2.8 PubMed:10338013, PubMed:19527031
right-to-left
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1- diphosphate 2.4.2.8 PubMed:10338013, PubMed:19527031
right-to-left
Cofactor: Evidence: Note:
Mg(2+) - Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.