Het-PDB Navi2 (PDB: 5W8K)

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Ligands
Code	Name	Link
9Y7	2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1h-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid	PoSSuM
GOL	Glycerol	PoSSuM
MLA	Malonic acid	PoSSuM
NAI	1,4-dihydronicotinamide adenine dinucleotide	PoSSuM

Non-standard Residues
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Download interaction data: 5W8K

Code :

5W8K PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 and NADH

Release Data :

2018-01-17

Compound :

mol_id	molecule	chains	synonym
1	L-lactate dehydrogenase A chain	A,B,C,D	LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59
	ec: 1.1.1.27

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: LDHA, PIG19 expression_system_vector_type: plasmid

Authors :

Lukacs, C.M., Dranow, D.M.

Keywords :

oxidoreductase, oxidoreductase inhibitor

Exp. method :

X-RAY DIFFRACTION ( 1.6000 Å )

Citation :

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai, G.,Brimacombe, K.R.,Mott, B.T. et al.
(2017) J. Med. Chem. 60 : 9184 - 9204

Chain :

A, B, C, D

UniProt :

P00338 (LDHA_HUMAN)

PDB ID: 5W8K