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Ligands
Code Name Style Show Link
9Y7 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1h-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid
DMS Dimethyl sulfoxide
GOL Glycerol
MLA Malonic acid
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Code : 5W8J   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29
Release Data : 2018-01-17
Compound :
mol_id molecule chains synonym
1 L-lactate dehydrogenase A chain A,B,C,D LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59
ec: 1.1.1.27
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: LDHA, PIG19
expression_system_vector_type: plasmid
Authors : Lukacs, C.M., Moulin, A.
Keywords : oxidoreductase, oxidoreductase inhibitor
Exp. method : X-RAY DIFFRACTION ( 1.5500 Å )
Citation :

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai, G.,Brimacombe, K.R.,Mott, B.T.  et al.
(2017)  J. Med. Chem.  60 : 9184 - 9204

PubMed: 29120638
DOI: 10.1021/acs.jmedchem.7b00941

Chain : A, B, C, D
UniProt : P00338 (LDHA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-lactate + NAD(+) = H(+) + NADH + pyruvate 1.1.1.27 PubMed:11276087
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