Het-PDB Navi2 (PDB: 5W86)

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Ligands
Code	Name		Style	Show	Link
9YV	4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 5W86

Code :

5W86 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 7)

Release Data :

2017-10-11

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK3	A,B,C,D	Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK
	ec: 2.7.10.2 fragment: KINASE DOMAIN (UNP RESIDUES 810-1100) mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK3 expression_system_common: FALL ARMYWORM expression_system_vector_type: BACULOVIRUS TRANSFER VECTOR

Authors :

Sack, J.S.

Keywords :

SERINE/THREONINE PROTEIN KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.61 Å )

Citation :

Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.

Bhide, R.S.,Keon, A.,Weigelt, C. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 4908 - 4913

Chain :

A, B, C, D

UniProt :

P52333 (JAK3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 5W86