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PDB ID: 5W6E

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Ligands
Code Name Style Show Link
0NY 7,8-dimethoxy-N-[(2s)-1-(3-methyl-1h-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 5W6E   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : PDE1b complexed with compound 3S
Release Data : 2018-05-30
Compound :
mol_id molecule chains synonym
1 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B A Cam-PDE 1B,63 kDa Cam-PDE
ec: 3.1.4.17
fragment: UNP residues 122-487
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PDE1B, PDE1B1, PDES1B
Authors : Vajdos, F.F.
Keywords : Phosphodiesterase, inhibitor, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

Humphrey, J.M.,Movsesian, M.,Am Ende, C.W.  et al.
(2018)  J. Med. Chem.  61 : 4635 - 4640

PubMed: 29718668
DOI: 10.1021/acs.jmedchem.8b00374

Reaction

Chain : A
UniProt : Q01064 (PDE1B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+) 3.1.4.17 PubMed:15260978, PubMed:8855339, PubMed:9419816
left-to-right PubMed:15260978
3',5'-cyclic GMP + H2O = GMP + H(+) - PubMed:15260978, PubMed:9419816
left-to-right PubMed:15260978
3',5'-cyclic AMP + H2O = AMP + H(+) - PubMed:15260978, PubMed:8855339, PubMed:9419816
left-to-right PubMed:15260978