Brand  (β version)

PDB ID: 5W4B

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Ligands
Code Name Style Show Link
NAD Nicotinamide-adenine-dinucleotide PoSSuM
9W4 4-[(2,5-dioxo-2,5-dihydro-1h-imidazol-1-yl)methyl]-N-[2-(morpholin-4-yl)-1,3-benzothiazol-6-yl]benzamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5W4B   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to benzothiazole inhibitor
Release Data : 2017-06-28
Compound :
mol_id molecule chains synonym
1 Adenosylhomocysteinase A,B,C,D,E,F AdoHcyase, S-adenosyl-L-homocysteine hydrolase
ec: 3.3.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: AHCY, SAHH
expression_system_strain: Rosetta 2(DE3) pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pSX70
Authors : Dougan, D.R., Lawson, J.D., Lane, W.
Keywords : HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.6500 Å )
Citation :

Identification of AHCY inhibitors using novel high-throughput mass spectrometry.

Uchiyama, N.,Dougan, D.R.,Lawson, J.D.  et al.
(2017)  Biochem. Biophys. Res. Commun.  491 : 1 - 7

PubMed: 28533090
DOI: 10.1016/j.bbrc.2017.05.107

Reaction

Chain : A, B, C, D, E, F
UniProt : P23526 (SAHH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine 3.13.2.1 PubMed:10933798
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