Brand  (β version)

PDB ID: 5W49

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9W1 (4-amino-1,2,5-oxadiazol-3-yl)[(3r)-3-{4-[(3-methoxyphenyl)amino]-6-methylpyridin-2-yl}pyrrolidin-1-yl]methanone PoSSuM
EDO 1,2-ethanediol PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5W49   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to oxadiazole inhibitor
Release Data : 2017-06-28
Compound :
mol_id molecule chains synonym
1 Adenosylhomocysteinase A,B AdoHcyase, S-adenosyl-L-homocysteine hydrolase
ec: 3.3.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: AHCY, SAHH
expression_system_strain: Rosetta 2(DE3) pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pSX70
Authors : Dougan, D.R., Lawson, J.D., Lane, W.
Keywords : HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Identification of AHCY inhibitors using novel high-throughput mass spectrometry.

Uchiyama, N.,Dougan, D.R.,Lawson, J.D.  et al.
(2017)  Biochem. Biophys. Res. Commun.  491 : 1 - 7

PubMed: 28533090
DOI: 10.1016/j.bbrc.2017.05.107

Reaction

Chain : A, B
UniProt : P23526 (SAHH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine 3.13.2.1 PubMed:10933798
left-to-right