Brand  (β version)

PDB ID: 5W3K

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Ligands
Code Name Style Show Link
9TY Cyclopropane-1,1-dicarboxylic acid PoSSuM
MG Magnesium ion PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 5W3K   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex NADPH, Mg2+ and CPD
Release Data : 2017-10-25
Compound :
mol_id molecule chains synonym
1 Ketol-acid reductoisomerase (NADP(+)) A,B KARI,Acetohydroxy-acid isomeroreductase,AHIR,Alpha-keto-beta-hydroxylacyl reductoisomerase
ec: 1.1.1.86
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:511693)
gene: ilvC, BMF23_13825, BO217_1422, ERS072840_02559
expression_system_strain: BL21
Authors : Patel, K.M., Teran, D., Zheng, S., Kandale, A., Schembri, M., McGeary, R.P., Schenk, G., Guddat, L.W.
Keywords : Ketol-acid reductisomerase, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.589 Å )
Citation :

Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.

Patel, K.M.,Teran, D.,Zheng, S.  et al.
(2017)  Chemistry  23 : 18289 - 18295

PubMed: 28975665
DOI: 10.1002/chem.201704481

Reaction

Chain : A, B
UniProt : A0A145BYP4
Reaction : -