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Ligands
Code Name Style Show Link
EP Epothilone a
GDP Guanosine-5'-diphosphate
GTP Guanosine-5'-triphosphate
MG Magnesium ion
Non-standard Residues
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Glycosylation
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Code : 5W3H   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Yeast microtubule stabilized with epothilone
Release Data : 2017-07-19
Compound :
mol_id molecule chains
1 Tubulin alpha-1 chain A
mol_id molecule chains synonym
2 Tubulin beta chain B Beta-tubulin
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
Authors : Howes, S.C., Geyer, E.A., LaFrance, B., Zhang, R., Kellogg, E.H., Westermann, S., Rice, L.M., Nogales, E.
Keywords : Cytoskeleton, tubulin, HYDROLASE
Exp. method : ELECTRON MICROSCOPY ( 4.0 Å )
Citation :

Structural differences between yeast and mammalian microtubules revealed by cryo-EM.

Howes, S.C.,Geyer, E.A.,LaFrance, B.  et al.
(2017)  J. Cell Biol.  216 : 2669 - 2677

PubMed: 28652389
DOI: 10.1083/jcb.201612195

Chain : A
UniProt : P09733 (TBA1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - UniProtKB:P68363
left-to-right
Chain : B
UniProt : P02557 (TBB_YEAST)
Reaction : -