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Ligands
Code Name Style Show Link
9SV 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione
UNX Unknown atom or ion
Non-standard Residues
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Glycosylation
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Code : 5W1Y   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : SETD8 in complex with a covalent inhibitor
Release Data : 2017-06-21
Compound :
mol_id molecule chains synonym
1 N-lysine methyltransferase KMT5A A,B H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8
ec: 2.1.1.-,2.1.1.43
mutation: C343S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: KMT5A, PRSET7, SET07, SET8, SETD8
expression_system_strain: BL21-V2R-pRARE2
expression_system_plasmid: pHIS2
Authors : Tempel, W., Yu, W., Li, Y., Blum, G., Luo, M., Pittella-Silva, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Keywords : structural genomics, Structural Genomics Consortium, SGC, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.7000 Å )
Citation :

SETD8 in complex with a covalent inhibitor

Tempel, W.,Yu, W.,Li, Y.  et al.
to be published 

Chain : A, B
UniProt : Q9NQR1 (KMT5A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine 2.1.1.361 PROSITE-ProRule:PRU00904, PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:27338793
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L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine - PubMed:17707234
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