Brand  (β version)

PDB ID: 5W19

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Ligands
Code Name Style Show Link
9TD 1-carboxy-1-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]azaniumyl}-2-[(3r)-2-oxo-2,3-dihydro-1h-indol-3-yl]ethan-1-ide PoSSuM
K Potassium ion PoSSuM
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Structure summary

Code : 5W19   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Tryptophan indole-lyase complex with oxindolyl-L-alanine
Release Data : 2018-06-06
Compound :
mol_id molecule chains synonym
1 Tryptophanase A,B,C,D L-tryptophan indole-lyase,TNase
ec: 4.1.99.1
Source :
mol_id organism_scientific expression_system
1 Proteus vulgaris  (taxid:585) Escherichia coli BL21(DE3)  (taxid:469008)
gene: tnaA
expression_system_plasmid: pET100b
Authors : Phillips, R.S., Wood, Z.A.
Keywords : pyridoxal-5'-phosphate, aminotransferase fold, tryptophan metabolism, inhibition, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism.

Phillips, R.S.,Buisman, A.A.,Choi, S.  et al.
(2018)  Acta Crystallogr D Struct Biol  74 : 748 - 759

PubMed: 30082510
DOI: 10.1107/S2059798318003352

Crystal structure of tryptophanase.

Isupov, M.N.,Antson, A.A.,Dodson, E.J.  et al.
(1998)  J. Mol. Biol.  276 : 603 - 623

PubMed: 9551100
DOI: 10.1006/jmbi.1997.1561

Interactions of tryptophan synthase, tryptophanase, and pyridoxal phosphate with oxindolyl-L-alanine and 2,3-dihydro-L-tryptophan: support for an indolenine intermediate in tryptophan metabolism.

Phillips, R.S.,Miles, E.W.,Cohen, L.A.
(1984)  Biochemistry  23 : 6228 - 6234

PubMed: 6395894

Reaction

Chain : A, B, C, D
UniProt : P28796 (TNAA_PROVU)
Reaction: EC: Evidence:
Physiological Direction:
L-tryptophan + H2O = indole + pyruvate + NH4(+) 4.1.99.1 -
-
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate - -