Brand  (β version)

PDB ID: 5W0Q

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Ligands
Code Name Style Show Link
9UG (2r)-N,2,7-trimethyl-2,3-dihydro-4h-1,4-benzoxazine-4-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5W0Q   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION REGULATOR/INHIBITOR
Title : CREBBP Bromodomain in complex with Cpd17 (N,2,7-trimethyl-2,3-dihydro-4H-benzo[B][1,4]oxazine-4-carboxamide)
Release Data : 2018-03-07
Compound :
mol_id molecule chains
1 CREB-binding protein A
ec: 2.3.1.48
fragment: Bromodomain, UNP residues 1082-1197
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CREBBP, CBP
Authors : Murray, J.M.
Keywords : CREBBP, Bromodomain, small molecule inhibitor, TRANSFERASE-INHIBITOR complex, TRANSCRIPTION REGULATOR-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.7000 Å )
Citation :

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero, F.A.,Murray, J.,Lai, K.W.  et al.
(2017)  J. Med. Chem.  60 : 9162 - 9183

PubMed: 28892380
DOI: 10.1021/acs.jmedchem.7b00796

Reaction

Chain : A
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+) 2.3.1.48 PubMed:21131905, PubMed:24616510
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L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826
(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L- lysyl-[protein] + CoA + H(+) - PubMed:38128537
left-to-right