Brand  (β version)

PDB ID: 5W0L

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Ligands
Code Name Style Show Link
9UD 1-{3-[7-(difluoromethyl)-6-(1-methyl-1h-pyrazol-4-yl)-3,4-dihydroquinolin-1(2h)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-C]pyridin-5-yl}ethan-1-one PoSSuM
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Glycosylation
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Structure summary

Code : 5W0L   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION REGULATOR/INHIBITOR
Title : CREBBP Bromodomain in complex with Cpd10 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-C]pyridin-5-yl)ethan-1-one)
Release Data : 2018-03-07
Compound :
mol_id molecule chains
1 CREB-binding protein A,B
ec: 2.3.1.48
fragment: Bromodomain, UNP residues 1082-1197
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CREBBP, CBP
Authors : Murray, J.M.
Keywords : CREBBP, Bromodomain, small molecule inhibitor, TRANSCRIPTION REGULATOR-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.5490 Å )
Citation :

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero, F.A.,Murray, J.,Lai, K.W.  et al.
(2017)  J. Med. Chem.  60 : 9162 - 9183

PubMed: 28892380
DOI: 10.1021/acs.jmedchem.7b00796

Reaction

Chain : A, B
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone] 2.3.1.48 PubMed:24616510
left-to-right
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826