Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9UD 1-{3-[7-(difluoromethyl)-6-(1-methyl-1h-pyrazol-4-yl)-3,4-dihydroquinolin-1(2h)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-C]pyridin-5-yl}ethan-1-one
Code : 5W0L
Header : TRANSCRIPTION REGULATOR/INHIBITOR
Title : CREBBP Bromodomain in complex with Cpd10 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-C]pyridin-5-yl)ethan-1-one)
Release Data : 2018-03-07
Compound :
mol_id molecule chains
1 CREB-binding protein A,B
ec: 2.3.1.48
fragment: Bromodomain, UNP residues 1082-1197
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CREBBP, CBP
Authors : Murray, J.M.
Keywords : CREBBP, Bromodomain, small molecule inhibitor, TRANSCRIPTION REGULATOR-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.5490 Å )
Citation :

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero, F.A.,Murray, J.,Lai, K.W.  et al.
(2017)  J. Med. Chem.  60 : 9162 - 9183

PubMed: 28892380
DOI: 10.1021/acs.jmedchem.7b00796

Chain : A, B
UniProt : Q92793 (CBP_HUMAN)
Reaction : Acetyl-CoA + [histone] = CoA + acetyl- [histone].