Brand  (β version)

PDB ID: 5W0I

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Ligands
Code Name Style Show Link
9UA 1-{3-[7-(difluoromethyl)-6-(1-methyl-1h-pyrazol-4-yl)-3,4-dihydroquinolin-1(2h)-yl]-1-[(3s)-oxolan-3-yl]-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-C]pyridin-5-yl}ethan-1-one PoSSuM
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 5W0I   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-C]pyridin-5-yl)ethan-1-one)
Release Data : 2018-03-07
Compound :
mol_id molecule chains
1 CREB-binding protein A
ec: 2.3.1.48
fragment: Bromodomain, UNP residues 1083-1198
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Crebbp, Cbp
Authors : Murray, J.M.
Keywords : CREBBP, Bromodomain, small molecule inhibitor, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.4300 Å )
Citation :

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero, F.A.,Murray, J.,Lai, K.W.  et al.
(2017)  J. Med. Chem.  60 : 9162 - 9183

PubMed: 28892380
DOI: 10.1021/acs.jmedchem.7b00796

Reaction

Chain : A
UniProt : P45481 (CBP_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+) 2.3.1.48 PubMed:11115394
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L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) - PubMed:15220471
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(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L- lysyl-[protein] + CoA + H(+) - UniProtKB:Q92793
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