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Ligands
Code Name Style Show Link
9QY Methyl 2-[2-(1-benzyl-1h-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate
FMT Formic acid
EDO 1,2-ethanediol
MG Magnesium ion
NA Sodium ion
Non-standard Residues
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Glycosylation
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Code : 5VYY   PDBj   RCSB PDB   PDBe
Header : CHAPERONE/INHIBITOR
Title : Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm
Release Data : 2018-04-18
Compound :
mol_id molecule chains synonym
1 Heat shock protein HSP 90-alpha A Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HSP90AA1, HSP90A, HSPC1, HSPCA
Authors : Que, N.S., Gewirth, D.T.
Keywords : chaperone, chaperone-inhibitor, CHAPERONE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.792 Å )
Citation :

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.

Que, N.L.S.,Crowley, V.M.,Duerfeldt, A.S.  et al.
(2018)  J. Med. Chem.  61 : 2793 - 2805

PubMed: 29528635
DOI: 10.1021/acs.jmedchem.7b01608

Chain : A
UniProt : P07900 (HS90A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.10 PubMed:12526792
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