Het-PDB Navi2 (PDB: 5VX3)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM

Non-standard Residues
Code	Name	Show
9R1	(2s)-2-aminooctanedioic acid

Glycosylation
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Download interaction data: 5VX3

Code :

5VX3 PDBj RCSB PDB PDBe

Header :

APOPTOSIS

Title :

Bcl-xL in complex with Bim-h3Pc-RT

Release Data :

2017-11-15

Compound :

mol_id	molecule	chains	synonym
1	Bcl-2-like protein 1	A,C,E,G	Bcl2-L-1,Apoptosis regulator Bcl-X,Bcl2-L-1,Apoptosis regulator Bcl-X
	fragment: UNP residues 1-26 and 83-209

mol_id	molecule	chains	synonym
2	Bcl-2-like protein 11	B,D,F,H	Bcl2-L-11,Bcl2-interacting mediator of cell death
	fragment: UNP residues 141-166 mutation: W147R, Y163T

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BCL2L1, BCL2L, BCLX

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Cowan, A.D., Brouwer, J.M., Colman, P.M., Czabotar, P.E.

Keywords :

Apoptosis, Bcl-2 Family, Pro-survival

Exp. method :

X-RAY DIFFRACTION ( 1.945 Å )

Citation :

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.

Brouwer, J.M.,Lan, P.,Cowan, A.D. et al.
(2017) Mol. Cell 68 : 659 - 672.e9

PDB ID: 5VX3