Het-PDB Navi2 (PDB: 5VX0)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
Code	Name	Show
9R7	L-gamma-glutamylglycine

Glycosylation
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Download interaction data: 5VX0

Code :

5VX0 PDBj RCSB PDB PDBe

Header :

APOPTOSIS

Title :

Bak in complex with Bim-h3Glg

Release Data :

2017-11-15

Compound :

mol_id	molecule	chains	synonym
1	Bcl-2 homologous antagonist/killer	A,C	Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7
	fragment: UNP residues 23-186 mutation: C166S

mol_id	molecule	chains	synonym
2	Bcl-2-like protein 11	B,D	Bcl2-L-11,Bcl2-interacting mediator of cell death
	fragment: UNP residues 141-166 mutation: W147R, Y163T

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BAK1, BAK, BCL2L7, CDN1

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Brouwer, J.M., Lan, P., Lessene, G., Colman, P.M., Czabotar, P.E.

Keywords :

Apoptosis, Bcl-2 Family, Inhibitor

Exp. method :

X-RAY DIFFRACTION ( 1.599 Å )

Citation :

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.

Brouwer, J.M.,Lan, P.,Cowan, A.D. et al.
(2017) Mol. Cell 68 : 659 - 672.e9

PDB ID: 5VX0