Het-PDB Navi2 (PDB: 5VWO)

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Ligands
Code	Name		Style	Show	Link
9QJ	(1s,3s,4e)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid				PoSSuM

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Download interaction data: 5VWO

Code :

5VWO PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Ornithine aminotransferase inactivated by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)

Release Data :

2017-08-30

Compound :

mol_id	molecule	chains	synonym
1	Ornithine aminotransferase, mitochondrial	A,B,C	Ornithine delta-aminotransferase,Ornithine--oxo-acid aminotransferase
	ec: 2.6.1.13 fragment: UNP residues 36-439

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: OAT

Authors :

Mascarenhas, R., Liu, D., Le, H., Silverman, R.

Keywords :

Aminotransferase, Mechanism-based inactivator, PLP, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.773 Å )

Citation :

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.

Mascarenhas, R.,Le, H.V.,Clevenger, K.D. et al.
(2017) Biochemistry 56 : 4951 - 4961

PubMed: 28816437
DOI: 10.1021/acs.biochem.7b00499

Chain :

A, B, C

UniProt :

P04181 (OAT_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5- semialdehyde	2.6.1.13	PubMed:1737786, PubMed:23076989
	right-to-left	PubMed:1737786

PDB ID: 5VWO

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Structure summary

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