Brand  (β version)

PDB ID: 5VWM

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Ligands
Code Name Style Show Link
C90 N-{(1s,2r)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
EDO 1,2-ethanediol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5VWM   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor
Release Data : 2017-06-07
Compound :
mol_id molecule chains synonym
1 UDP-3-O-acyl-N-acetylglucosamine deacetylase A UDP-3-O-acyl-GlcNAc deacetylase,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
ec: 3.5.1.108
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)  (taxid:208964) Escherichia coli  (taxid:469008)
strain: ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
gene: lpxC, envA, PA4406
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PsaeA.00166.a.DG15
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : inhibitor, Seattle Structural Genomics Center for Infectious Disease, SSGCID, LpxC, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.8000 Å )
Citation :

Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor

Delker, S.L.,Mayclin, S.J.,Phan, J.N.  et al.
to be published 

Reaction

Chain : A
UniProt : P47205 (LPXC_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388, PubMed:9068651
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