Brand  (β version)

PDB ID: 5VTA

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Ligands
Code Name Style Show Link
PG4 Tetraethylene glycol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
EDO 1,2-ethanediol PoSSuM
9K4 2-{4-[(3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]piperazin-1-yl}-N-(22-oxo-3,6,9,12,15,18-hexaoxa-21-azatricosan-1-yl)acetamide PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 5VTA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Co-Crystal Structure of DPPIV with a Chemibody Inhibitor
Release Data : 2018-05-09
Compound :
mol_id molecule chains synonym
1 Dipeptidyl peptidase 4 A,B,C,D Bile canaliculus domain-specific membrane glycoprotein,Dipeptidyl peptidase IV,DPP IV,GP110 glycoprotein,T-cell activation antigen CD26
ec: 3.4.14.5
fragment: residues 37-767
mol_id molecule chains
2 Fab light chain L,E,G,J
mol_id molecule chains
3 Fab heavy chain H,F,I,K
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Homo sapiens  (taxid:9606)
gene: Dpp4, Cd26
expression_system_common: Human
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) Mouse Homo sapiens  (taxid:9606)
expression_system_common: Human
mol_id organism_scientific organism_common expression_system
3 Mus musculus  (taxid:10090) Mouse Homo sapiens  (taxid:9606)
expression_system_common: Human
Authors : Wang, Z., Johnstone, S., Cheng, A.
Keywords : hydrolase, chemibody
Exp. method : X-RAY DIFFRACTION ( 2.8000 Å )
Citation :

Structure-guided Discovery of Dual-recognition Chemibodies.

Cheng, A.C.,Doherty, E.M.,Johnstone, S.  et al.
(2018)  Sci Rep  8 : 7570 - 7570

PubMed: 29765112
DOI: 10.1038/s41598-018-25848-0

Reaction

Chain : A, B, C, D
UniProt : P14740 (DPP4_RAT)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 UniProtKB:P27487, PROSITE- ProRule:PRU10084
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