Brand  (β version)

PDB ID: 5VSK

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Ligands
Code Name Style Show Link
9HS 7-chloro-3-({4-hydroxy-1-[(3s)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3h)-one PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5VSK   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Structure of DUB complex
Release Data : 2017-12-20
Compound :
mol_id molecule chains synonym
1 Ubiquitin carboxyl-terminal hydrolase 7 A,B Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7
ec: 3.4.19.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: USP7, HAUSP
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Seo, H.-Y., Dhe-Paganon, S.
Keywords : deubiquitinase, inhibitor, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 3.3300 Å )
Citation :

Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Lamberto, I.,Liu, X.,Seo, H.S.  et al.
(2017)  Cell Chem Biol  24 : 1490 - 1500.e11

PubMed: 29056421
DOI: 10.1016/j.chembiol.2017.09.003

Reaction

Chain : A, B
UniProt : Q93009 (UBP7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal). 3.4.19.12 PubMed:11923872, PubMed:12507430, PubMed:14506283, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:21745816, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969
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