PDB ID: 5VQZ
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Code | Name | Style | Show | Link | |
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9HY | N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-N-methylacetamide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 5VQZ
Structure summary
Code : | 5VQZ PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE/HYDROLASE/INHIBITOR | ||||||||||||||||||||||||
Title : | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor | ||||||||||||||||||||||||
Release Data : | 2017-08-23 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Buckingham, A.B., Chan, A.H., Anderson, K.S. | ||||||||||||||||||||||||
Keywords : | Polymerase, reverse transcriptase, HIV, non-nucleoside inhibitor, TRANSFERASE, HYDROLASE-INHIBITOR complex, TRANSFERASE-HYDROLASE-INHIBITOR complex | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.2300 Å ) | ||||||||||||||||||||||||
Citation : |
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Chan, A.H.,Lee, W.G.,Spasov, K.A.
et al.
PubMed: 28827354 |
Reaction
Chain : | B | ||||||||||||||||||||||||
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UniProt : | P03366 (POL_HV1B1) | ||||||||||||||||||||||||
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