Brand  (β version)

PDB ID: 5VPS

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Ligands
Code Name Style Show Link
9G1 [(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]piperidin-4-yl]-tris(3-hydroxy-3-oxopropyl)phosphanium PoSSuM
EDO 1,2-ethanediol PoSSuM
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Structure summary

Code : 5VPS   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of an SDR from Burkholderia ambifaria in complex with NADPH with a TCEP adduct
Release Data : 2017-05-24
Compound :
mol_id molecule chains
1 Short-chain dehydrogenase/reductase SDR A
Source :
mol_id organism_scientific expression_system
1 Burkholderia ambifaria (strain MC40-6)  (taxid:398577) Escherichia coli  (taxid:469008)
strain: MC40-6
gene: BamMC406_2208
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: BuamA.00010.o.B1
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : SGCID, short chain, dehydrogenase, reductase, NADP, NADPH, TCEP, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes.

Patel, S.M.,Smith, T.G.,Morton, M.  et al.
(2020)  Biochemistry 

PubMed: 32841567
DOI: 10.1021/acs.biochem.0c00490

Reaction

Chain : A
UniProt : B1YU47 (B1YU47_BURA4)
Reaction : -