Brand  (β version)

PDB ID: 5VPM

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Ligands
Code Name Style Show Link
9G7 Methyl [(4s)-4-(3'-ethyl-6-fluoro[1,1'-biphenyl]-2-yl)-4-hydroxy-4-{(3r)-1-[(piperidin-4-yl)acetyl]piperidin-3-yl}butyl]carbamate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 5VPM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE inhibitor
Title : Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol
Release Data : 2017-10-18
Compound :
mol_id molecule chains synonym
1 Renin A,B Angiotensinogenase
ec: 3.4.23.15
fragment: UNP residues 70-406
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: REN
expression_system_common: Human
expression_system_cell_line: HEK-F
Authors : Concha, N., Zhao, B.
Keywords : renin inhibitor, biphenyl, hypertension, Cyp 3A4, HYDROLASE-HYDROLASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.

Lawhorn, B.G.,Tran, T.,Hong, V.S.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 4838 - 4843

PubMed: 28985999
DOI: 10.1016/j.bmcl.2017.09.046

Reaction

Chain : A, B
UniProt : P00797 (RENI_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. 3.4.23.15 PubMed:12045255, PubMed:20927107
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