Brand  (β version)

PDB ID: 5VP8

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
9HD 1-[(3r,5s,7r)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2h-pyrrol-2-one PoSSuM
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Structure summary

Code : 5VP8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : I38T mutant of 2009 H1N1 PA Endonuclease
Release Data : 2018-04-11
Compound :
mol_id molecule chains
1 Polymerase acidic protein A
mutation: I38T, Loop replaced with GGS linker
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:641501) Escherichia coli  (taxid:469008)
strain: swl A/California/04/2009 H1N1
gene: PA
expression_system_strain: BL21(DE3)
Authors : Kumar, G., White, S.W.
Keywords : Nuclease Influenza Resistance RO-7, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.2000 Å )
Citation :

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.

Jones, J.C.,Kumar, G.,Barman, S.  et al.
(2018)  MBio  9

PubMed: 29691337
DOI: 10.1128/mBio.00430-18

Reaction

Chain : A
UniProt : C3W5S0 (PA_I09A0)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_04063
ECO:0000269 | PubMed:22876177
ECO:0000269 | PubMed:26976575
ECO:0000269 | PubMed:27510745
ECO:0000269 | PubMed:29215062
Binds 2 manganese ions per subunit.