Het-PDB Navi2 (PDB: 5VOF)

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Color scheme of protein:

Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
MG	Magnesium ion	PoSSuM
NA	Sodium ion	PoSSuM
RIV	5-chloro-N-({(5s)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide	PoSSuM

Non-standard Residues
Code	Name	Show
CFL	4-amino-1-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)pyrimidin-2(1h)-one
UFT	2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate)

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5VOF

Code :

5VOF PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR/RNA

Title :

DesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban

Release Data :

2018-06-13

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor X	H	Stuart factor,Stuart-Prower factor
	ec: 3.4.21.6 fragment: residue 235-467 mutation: S419A

mol_id	molecule	chains	synonym
2	Coagulation factor X	L	Stuart factor,Stuart-Prower factor
	ec: 3.4.21.6 fragment: residues 128-178

mol_id	molecule	chains
3	DNA/RNA (36-MER)	A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F10 expression_system_common: Human expression_system_cell_line: HEK293

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F10 expression_system_common: Human expression_system_cell_line: HEK293

mol_id	organism_scientific
3	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Krishnaswamy, S., Kumar, S.

Keywords :

Serine Protease, Blood Coagulation, Aptamer, Inhibitor, HYDROLASE-HYDROLASE INHIBITOR-RNA complex

Exp. method :

X-RAY DIFFRACTION ( 2.25 Å )

Citation :

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.

Gunaratne, R.,Kumar, S.,Frederiksen, J.W. et al.
(2018) Nat. Biotechnol. 36 : 606 - 613

Chain :

UniProt :

P00742 (FA10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Thr and then Arg-\|-Ile bonds in prothrombin to form thrombin.	3.4.21.6	-
	-	-

PDB ID: 5VOF