Het-PDB Navi2 (PDB: 5VOE)

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Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
MG	Magnesium ion	PoSSuM
NA	Sodium ion	PoSSuM

Non-standard Residues
Code	Name	Show
CFL	4-amino-1-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)pyrimidin-2(1h)-one
UFT	2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate)

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5VOE

Code :

5VOE PDBj RCSB PDB PDBe

Header :

HYDROLASE/RNA

Title :

DesGla-XaS195A Bound to Aptamer 11F7t

Release Data :

2018-06-20

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor X	H	Stuart factor,Stuart-Prower factor
	ec: 3.4.21.6 fragment: residues 235-467 mutation: S419A

mol_id	molecule	chains	synonym
2	Coagulation factor X	L	Stuart factor,Stuart-Prower factor
	ec: 3.4.21.6 fragment: residues 128-178

mol_id	molecule	chains
3	Aptamer 11F7t (36-MER)	A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F10 expression_system_common: Human expression_system_cell_line: HEK293

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F10 expression_system_common: Human expression_system_cell_line: HEK293

mol_id	organism_scientific
3	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Gunaratne, R., Kumar, S., Frederiksen, J.W., Stayrook, S., Lohrmann, J.L., Perry, K., Chabata, C.V., Thalji, N.K., Ho, M.D., Arepally, G., Camire, R.M., Krishnaswamy, S.K., Sullenger, B.A.

Keywords :

Serine Protease, Blood Coagulation, Aptamer, Inhibitor, HYDROLASE-RNA complex

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.

Gunaratne, R.,Kumar, S.,Frederiksen, J.W. et al.
(2018) Nat. Biotechnol. 36 : 606 - 613

PubMed: 29863725
DOI: 10.1038/nbt.4153

Chain :

UniProt :

P00742 (FA10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Thr and then Arg-\|-Ile bonds in prothrombin to form thrombin.	3.4.21.6	-
	-	-

PDB ID: 5VOE

Hetero Atom Contents

Structure summary

Reaction