Het-PDB Navi2 (PDB: 5VO6)

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Ligands
Code	Name		Style	Show	Link
9J4	4-{[(1r,3s)-3-amino-2,2,3-trimethylcyclopentyl]amino}-6-phenylpyrrolo[1,2-B]pyridazine-3-carboxamide				PoSSuM

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Download interaction data: 5VO6

Code :

5VO6 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRIDAZINE INHIBITOR

Release Data :

2017-05-31

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK3	A	Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK
	ec: 2.7.10.2 fragment: KINASE DOMAIN (UNP RESIDUES 810-1100) mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK3 expression_system_common: FALL ARMYWORM expression_system_vector_type: BACULOVIRUS TRANSFER VECTOR

Authors :

Sack, J.S.

Keywords :

TRANSFERASE, TRANSFERASE-INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.65 Å )

Citation :

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.

Hynes, J.,Wu, H.,Kempson, J. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 3101 - 3106

Chain :

UniProt :

P52333 (JAK3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 5VO6