Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9FV 5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 5VO2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE Inhibitor
Title : DLK in complex with inhibitor 5-(1-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine (compound 7)
Release Data : 2017-10-04
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase kinase kinase 12 A Dual leucine zipper bearing kinase,DLK,Leucine-zipper protein kinase,ZPK,MAPK-upstream kinase,MUK,Mixed lineage kinase
ec: 2.7.11.25
fragment: UNP residues 115-402
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: MAP3K12, ZPK
expression_system_vector_type: baculovirus
Authors : HARRIS, S.F., YIN, J.
Keywords : kinase, TRANSFERASE-TRANSFERASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.9600 Å )
Citation :

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Patel, S.,Meilandt, W.J.,Erickson, R.I.  et al.
(2017)  J. Med. Chem.  60 : 8083 - 8102

PubMed: 28929759
DOI: 10.1021/acs.jmedchem.7b00843

Chain : A
UniProt : Q12852 (M3K12_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.25 UniProtKB:Q60700
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.25 UniProtKB:Q60700
-