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Ligands
Code Name Style Show Link
NI Nickel (II) ion
ZN Zinc ion
9FJ 3-({[(1r)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid
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Code : 5VMP   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/INHIBITOR
Title : Crystal Structure of Human KDM4 with Small Molecule Inhibitor QC5714
Release Data : 2017-09-27
Compound :
mol_id molecule chains synonym
1 Lysine-specific demethylase 4A A,B,C,D JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A
ec: 1.14.11.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
Authors : Hosfield, D.J.
Keywords : KDM4, Inhibitor-complex, demethylase, epigenetics, OXIDOREDUCTASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4800 Å )
Citation :

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.

Chen, Y.K.,Bonaldi, T.,Cuomo, A.  et al.
(2017)  ACS Med Chem Lett  8 : 869 - 874

PubMed: 28835804
DOI: 10.1021/acsmedchemlett.7b00220

Chain : A, B, C, D
UniProt : O75164 (KDM4A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(9)-[histone H3] + 2 succinate 1.14.11.66 PubMed:16603238
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2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(36)-[histone H3] + 2 succinate 1.14.11.69 PubMed:16603238
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