Het-PDB Navi2 (PDB: 5VHB)

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Ligands
Code	Name		Style	Show	Link
9CY	N-[(2s)-1-hydroxy-3-phenylpropan-2-yl]-4-(pyridin-4-yl)benzamide				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5VHB

Code :

5VHB PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitor

Release Data :

2018-01-31

Compound :

mol_id	molecule	chains	synonym
1	cAMP-dependent protein kinase catalytic subunit alpha	A	PKA C-alpha
	ec: 2.7.11.11 mutation: T198(TPO), S140(SEP), S339(SEP)

mol_id	molecule	chains	synonym
2	PKI peptide	B	PKI-alpha
	fragment: UNP residues 6-23

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bos taurus (taxid:9913)	Bovine	Escherichia coli (taxid:562)
	gene: PRKACA expression_system_strain: Rosetta2(DE3)T1R

mol_id	organism_scientific	organism_common
2	Bos taurus (taxid:9913)	Bovine
	synthetic: yes

Authors :

Judge, R.A.

Keywords :

Kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.61 Å )

Citation :

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate.

Judge, R.A.,Vasudevan, A.,Scott, V.E. et al.
(2018) Chembiochem 19 : 613 - 621

Chain :

UniProt :

P00517 (KAPCA_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.11	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.11	-
	-	-

PDB ID: 5VHB