Brand  (β version)

PDB ID: 5VFD

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Ligands
Code Name Style Show Link
9CM (2s,5r)-4-methyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide PoSSuM
9CP (2s,5r)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
KCX Lysine nz-carboxylic acid
Glycosylation
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Structure summary

Code : 5VFD   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii
Release Data : 2017-06-07
Compound :
mol_id molecule chains synonym
1 Beta-lactamase A Betalactamase OXA24,Carbapenem-hydrolyzing beta-lactamase OXA-40,Carbapenem-hydrolyzing oxacillinase,Carbapenem-hydrolyzing oxacillinase OXA-40,Carbapenemase OXA-24,Class D beta-lactamase,Class D beta-lactamase OXA-40,OXA24 B-lactamase,Oxa40
mutation: K84KCX
Source :
mol_id organism_scientific expression_system
1 Acinetobacter baumannii  (taxid:470) Escherichia coli  (taxid:511693)
gene: blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40, A8G88_08245
expression_system_strain: BL21
Authors : Olivier, N.B., Lahiri, S.
Keywords : ETX2514, beta-lactamase, PBP Gram negative, Astrazeneca, Entasis, A. baumannii, covalent inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.93 Å )
Citation :

ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.

Durand-Reville, T.F.,Guler, S.,Comita-Prevoir, J.  et al.
(2017)  Nat Microbiol  2 : 17104 - 17104

PubMed: 28665414
DOI: 10.1038/nmicrobiol.2017.104

Reaction

Chain : A
UniProt : Q8RLA6 (Q8RLA6_ACIBA)
Reaction : -