PDB ID: 5VFC
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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9BA | N-{(3r,6s,9s,12r)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 5VFC
Structure summary
Code : | 5VFC PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSCRIPTION/INHIBITOR | ||||||||||||
Title : | WDR5 bound to inhibitor MM-589 | ||||||||||||
Release Data : | 2017-06-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Stuckey, J.A. | ||||||||||||
Keywords : | inhibitor, complex, WD repeat, TRANSCRIPTION, TRANSCRIPTION-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.64 Å ) | ||||||||||||
Citation : |
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
Karatas, H.,Li, Y.,Liu, L.
et al.
PubMed: 28603984 |
Reaction
Chain : | A |
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UniProt : | P61964 (WDR5_HUMAN) |
Reaction : | - |