Brand  (β version)

PDB ID: 5VEW

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Ligands
Code Name Style Show Link
97Y N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1h-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
OLA Oleic acid PoSSuM
Non-standard Residues
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CSD 3-sulfinoalanine
Glycosylation
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Structure summary

Code : 5VEW   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of the human GLP-1 receptor complex with PF-06372222
Release Data : 2017-05-24
Compound :
mol_id molecule chains synonym
1 Glucagon-like peptide 1 receptor,Endolysin chimera A,B GLP-1R,Lysis protein,Lysozyme,Muramidase,GLP-1R
ec: 3.2.1.17
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GLP1R
expression_system_common: Fall armyworm
Authors : Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Keywords : GPCR, class B, 7TM domain, treatment of type 2 diabetes, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song, G.,Yang, D.,Wang, Y.  et al.
(2017)  Nature  546 : 312 - 315

PubMed: 28514449
DOI: 10.1038/nature22378

Reaction

Chain : A, B
UniProt : P43220 (GLP1R_HUMAN)
Reaction : -
Chain : A, B
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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