Brand  (β version)

PDB ID: 5VEE

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Ligands
Code Name Style Show Link
981 6-(2,4-dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-D]pyrimidin-7(8h)-one PoSSuM
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Structure summary

Code : 5VEE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : PAK4 kinase domain in complex with FRAX486
Release Data : 2017-10-18
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PAK 4 A p21-activated kinase 4,PAK-4
ec: 2.7.11.1
fragment: UNP residues 286-591
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PAK4, KIAA1142
expression_system_strain: BL21(DE3)RILP
expression_system_vector_type: PLASMID
expression_system_plasmid: MODIFIED PET VECTOR
Authors : Zhang, E.Y., Ha, B.H., Boggon, T.J.
Keywords : Kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

PAK4 crystal structures suggest unusual kinase conformational movements.

Zhang, E.Y.,Ha, B.H.,Boggon, T.J.
(2018)  Biochim. Biophys. Acta  1866 : 356 - 365

PubMed: 28993291
DOI: 10.1016/j.bbapap.2017.10.004

Reaction

Chain : A
UniProt : O96013 (PAK4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-