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Ligands
Code Name Style Show Link
7C6 (3s,3as,9bs)-2-[(2h-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4h-pyrrolo[3,4-C][1,6]naphthyridin-4-one
CL Chloride ion
GLY Glycine
IVM (2ae,4e,5'S,6s,6'R,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
ZN Zinc ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 5VDH   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin
Release Data : 2017-05-24
Compound :
mol_id molecule chains
1 Glycine receptor subunit alpha-3 A,B,C,D,E
fragment: UNP residues 34-342, ATG linker, UNP residues 419-460
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GLRA3
expression_system_common: Fall armyworm
Authors : Shaffer, P.L., Huang, X., Chen, H.
Keywords : Ligand-gated Ion Channel, Neurotransmitter Receptor, Membrane Protein, Cys-loop receptor, Transport Protein
Exp. method : X-RAY DIFFRACTION ( 2.85 Å )
Citation :

Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin.

Huang, X.,Chen, H.,Shaffer, P.L.
(2017)  Structure  25 : 945 - 950.e2

PubMed: 28479061
DOI: 10.1016/j.str.2017.04.007

Chain : A, B, C, D, E
UniProt : O75311 (GLRA3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride(in) = chloride(out) - PubMed:26416729, PubMed:9677400
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