Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
98D 1-{6-[(1s)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-D]pyrimidin-3-one
CL Chloride ion
EDO 1,2-ethanediol
Code : 5VDA
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of human WEE1 kinase domain in complex with RAC-IV-101, a MK1775 analogue
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 Wee1-like protein kinase A WEE1hu,Wee1A kinase
ec: 2.7.10.2
fragment: UNP RESIDUES 291-575
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:469008)
gene: WEE1
expression_system_strain: BL21(DE3)-RIPL
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a
Authors : Zhu, J.-Y., Schonbrunn, E.
Keywords : KINASE DOMAIN, CELL CYCLE, WEE1, TRANSFERASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Structural basis of Wee family kinase inhibition by small molecules

Zhu, J.-Y.,Schonbrunn, E.
to be published 

Chain : A
UniProt : P30291 (WEE1_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.