Brand  (β version)

PDB ID: 5VB5

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Ligands
Code Name Style Show Link
92A N-[(2r)-3-(4-{[3-(4-chlorophenyl)propanoyl]amino}phenyl)-1-(4-methylpiperidin-1-yl)-1-oxopropan-2-yl]-4-methylpentanamide PoSSuM
NA Sodium ion PoSSuM
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Structure summary

Code : 5VB5   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide
Release Data : 2017-06-07
Compound :
mol_id molecule chains synonym
1 Nuclear receptor ROR-gamma, SRC2 chimera A Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma,RORgt, RETINOID-RELATED ORPHAN RECEPTOR-GAMMA
fragment: residues 260-507
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
gene: RORC, NR1F3, RORG, RZRG
expression_system_strain: BL21(DE3)
Authors : Li, X.
Keywords : NUCLEAR RECEPTOR, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.226 Å )
Citation :

Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.

Li, X.,Anderson, M.,Collin, D.  et al.
(2017)  J. Biol. Chem.  292 : 11618 - 11630

PubMed: 28546429
DOI: 10.1074/jbc.M117.789024

Reaction

Chain : A
UniProt : P51449 (RORG_HUMAN)
Reaction : -