Brand  (β version)

PDB ID: 5VAR

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Ligands
Code Name Style Show Link
92Y (1r,2s,3r,4s)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5VAR   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor
Release Data : 2018-03-28
Compound :
mol_id molecule chains synonym
1 Lysine-specific demethylase 4A A JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A
ec: 1.14.11.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
Authors : Judge, R.A., Upadhyay, A.K.
Keywords : KDM4A tandem TUDOR domain, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.8300 Å )
Citation :

Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.

Upadhyay, A.K.,Judge, R.A.,Li, L.  et al.
(2018)  Bioorg. Med. Chem. Lett.  28 : 1708 - 1713

PubMed: 29691138
DOI: 10.1016/j.bmcl.2018.04.050

Reaction

Chain : A
UniProt : O75164 (KDM4A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(9)-[histone H3] + 2 succinate 1.14.11.66 PubMed:16603238
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2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(36)-[histone H3] + 2 succinate 1.14.11.69 PubMed:16603238
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