Het-PDB Navi2 (PDB: 5V9L)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
GDP	Guanosine-5'-diphosphate	PoSSuM
MG	Magnesium ion	PoSSuM
91D	N~3~-[6-chloro-7-(2-fluorophenyl)-4-(4-propanoylpiperazin-1-yl)quinazolin-2-yl]-N,N-dimethyl-beta-alaninamide	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5V9L

Code :

5V9L PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE inhibitor

Title :

KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder

Release Data :

2017-08-23

Compound :

mol_id	molecule	chains	synonym
1	GTPase KRas	A,B,C	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli K-12 (taxid:83333)
	gene: KRAS, KRAS2, RASK2

Authors :

Westover, K., Lu, J.

Keywords :

KRAS mutant inhibitor, HYDROLASE-HYDROLASE inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.9810 Å )

Citation :

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

Zeng, M.,Lu, J.,Li, L. et al.
(2017) Cell Chem Biol 24 : 1005 - 1016.e3

PDB ID: 5V9L