Brand  (β version)

PDB ID: 5V9I

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
SAM S-adenosylmethionine PoSSuM
90P N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine PoSSuM
GOL Glycerol PoSSuM
UNX Unknown atom or ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5V9I   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of catalytic domain of G9a with MS0105
Release Data : 2018-03-21
Compound :
mol_id molecule chains synonym
1 Histone-lysine N-methyltransferase EHMT2 A,B,C,D Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a
ec: 2.1.1.-,2.1.1.43
fragment: residues 913-1193
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: P28A-LIC
Authors : Dong, A., Zeng, H., Liu, J., Xiong, Y., Babault, N., Jin, J., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Wu, H., Brown, P.J., Structural Genomics Consortium (SGC)
Keywords : EHMT2, BAT8, methyltransferase, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.7400 Å )
Citation :

Crystal structure of catalytic domain of G9a with MS0105

Zeng, H.,Dong, A.,Liu, J.  et al.
to be published 

Reaction

Chain : A, B, C, D
UniProt : Q96KQ7 (EHMT2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L- homocysteine + H(+) - PubMed:11316813, PubMed:20084102
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L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)- methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+) 2.1.1.367 PubMed:11316813, PubMed:20084102
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