Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
90D Methyl [(4s)-4-(3'-ethyl-6-fluoro[1,1'-biphenyl]-2-yl)-4-hydroxy-4-{(3r)-1-[4-(methylamino)butanoyl]piperidin-3-yl}butyl]carbamate
NAG N-acetyl-D-glucosamine
Code : 5V8V
Header : HYDROLASE/HYDROLASE inhibitor
Title : Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol
Release Data : 2017-10-18
Compound :
mol_id molecule chains synonym
1 Renin A,B Angiotensinogenase
ec: 3.4.23.15
fragment: UNP residues 70-406
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Baculoviridae  (taxid:10442)
gene: REN
expression_system_cell: HEK-F
expression_system_vector_type: baculovirus
Authors : Concha, N., Zhao, B.
Keywords : renin inhibitor, biphenyl, hypertension, Cyp 3A4, HYDROLASE-HYDROLASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.

Lawhorn, B.G.,Tran, T.,Hong, V.S.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 4838 - 4843

PubMed: 28985999
DOI: 10.1016/j.bmcl.2017.09.046

Chain : A, B
UniProt : P00797 (RENI_HUMAN)
Reaction : Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.