Het-PDB Navi2 (PDB: 5V84)

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Ligands
Code	Name		Style	Show	Link
96V	N,2-dimethyl-7-oxo-N-{1-[(1s)-1-phenylethyl]piperidin-4-yl}-6-(prop-2-en-1-yl)-6,7-dihydro-1h-pyrrolo[2,3-C]pyridine-4- carboxamide				PoSSuM
SO4	Sulfate ion				PoSSuM

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Download interaction data: 5V84

Code :

5V84 PDBj RCSB PDB PDBe

Header :

Transcription/Inhibitor

Title :

CECR2 in complex with Cpd6 (6-allyl-N,2-dimethyl-7-oxo-N-(1-(1-phenylethyl)piperidin-4-yl)-6,7-dihydro-1H-pyrrolo[2,3-C]pyridine-4-carboxamide)

Release Data :

2017-06-14

Compound :

mol_id	molecule	chains
1	Cat eye syndrome critical region protein 2	A,B,C,D
	fragment: UNP residues 404-518

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CECR2, KIAA1740

Authors :

Murray, J.M., Kiefer, J.R., Jayaran, H., Bellon, S., Boy, F.

Keywords :

Bromodomain, SBDD, Transcription-Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.7000 Å )

Citation :

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).

Crawford, T.D.,Audia, J.E.,Bellon, S. et al.
(2017) ACS Med Chem Lett 8 : 737 - 741

PDB ID: 5V84