Het-PDB Navi2 (PDB: 5V80)

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Ligands
Code	Name		Style	Show	Link
971	1-methyl-4-{3-[6-(piperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[3,4-C]pyridin-5-yl}piperazin-2-one				PoSSuM
PO4	Phosphate ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5V80

Code :

5V80 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

PIM1 kinase in complex with Cpd1 (1-methyl-4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridin-5-yl)piperazin-2-one)

Release Data :

2018-04-18

Compound :

mol_id	molecule	chains
1	Serine/threonine-protein kinase pim-1	A
	ec: 2.7.11.1 fragment: UNP residues 29-313

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: PIM1 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid

Authors :

Murray, J.M., Wallweber, H.

Keywords :

PIM1, SBDD, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.2520 Å )

Citation :

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

Wang, X.,Kolesnikov, A.,Tay, S. et al.
(2017) J. Med. Chem. 60 : 4458 - 4473

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394, PubMed:37797010
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:37797010
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:15525646 ECO:0000269 \| PubMed:15657054 ECO:0000269 \| PubMed:15808862	-

PDB ID: 5V80