Het-PDB Navi2 (PDB: 5V7T)

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Ligands
Code	Name		Style	Show	Link
91V	N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-B]pyridazin-6-amine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5V7T

Code :

5V7T PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

crystal structure of PARP14 bound to N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-B]pyridazin-6-amine inhibitor

Release Data :

2017-05-03

Compound :

mol_id	molecule	chains	synonym
1	Poly [ADP-ribose] polymerase 14	A	PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2
	ec: 2.4.2.30

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PARP14, BAL2, KIAA1268

Authors :

saikatendu, k.s., Hirozane, M.

Keywords :

human parp14, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.

Yoneyama-Hirozane, M.,Matsumoto, S.I.,Toyoda, Y. et al.
(2017) Biochem. Biophys. Res. Commun. 486 : 626 - 631

Chain :

UniProt :

Q460N5 (PAR14_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide	-	PubMed:27796300
	left-to-right	PubMed:27796300

PDB ID: 5V7T