Het-PDB Navi2 (PDB: 5V0A)

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Ligands
Code	Name	Link
DA	2'-deoxyadenosine-5'-monophosphate	PoSSuM
MN	Manganese (II) ion	PoSSuM
NA	Sodium ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5V0A

Code :

5V0A PDBj RCSB PDB PDBe

Header :

HYDROLASE/DNA

Title :

Crystal structure of human exonuclease 1 Exo1 (D225A) in complex with 5' recessed-end DNA (rVIII)

Release Data :

2017-05-24

Compound :

mol_id	molecule	chains	synonym
1	Exonuclease 1	Z	hExo1, Exonuclease I, hExoI
	ec: 3.1.-.- fragment: UNP residues 1-352 mutation: D225A

mol_id	molecule	chains
2	DNA (5'-D(CPGPCPTPAPGPTPCPGPTPCPAP*T)-3')	A

mol_id	molecule	chains
3	DNA (5'-D(PCPGPAPCPTPAPGPCP*G)-3')	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: EXO1, EXOI, HEX1

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

mol_id	organism_scientific
3	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Shi, Y., Beese, L.S.

Keywords :

exonuclease, endonuclease, HYDROLASE-DNA complex

Exp. method :

X-RAY DIFFRACTION ( 2.38 Å )

Citation :

Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.

Shi, Y.,Hellinga, H.W.,Beese, L.S.
(2017) Proc. Natl. Acad. Sci. U.S.A. 114 : 6010 - 6015

PDB ID: 5V0A