Het-PDB Navi2 (PDB: 5UQE)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
04A	N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide)				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5UQE

Code :

5UQE PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Multidomain structure of human kidney-type glutaminase(KGA/GLS)

Release Data :

2017-05-24

Compound :

mol_id	molecule	chains	synonym
1	Glutaminase kidney isoform, mitochondrial	A,B,C,D,F	GLS,K-glutaminase,L-glutamine amidohydrolase
	ec: 3.5.1.2 fragment: UNP residues 137-656

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GLS, GLS1, KIAA0838 expression_system_strain: Rosetta-2 expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Pasquali, C.C., Dias, S.M.G., Ambrosio, A.L.B.

Keywords :

Glutaminase, human, kidney-type, KGA, GLS, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 3.600 Å )

Citation :

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.

Pasquali, C.C.,Islam, Z.,Adamoski, D. et al.
(2017) J. Biol. Chem. 292 : 11572 - 11585

Chain :

A, B, C, D, F

UniProt :

O94925 (GLSK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + L-glutamine = L-glutamate + NH4(+)	3.5.1.2	PubMed:22049910, PubMed:22538822, PubMed:24451979, PubMed:26988803, PubMed:28526749, PubMed:29317493
H2O + L-glutamine = L-glutamate + NH4(+)	-

PDB ID: 5UQE